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NEK1
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. High fetal expression in the brain and kidney. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; NEK family; NEK1 subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 8 B3.1|8 30.91 cM |
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Cellular Component:
centriolar satellite; centrosome; cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus; pericentriolar material
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Molecular Function:
14-3-3 protein binding; ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity
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Biological Process:
cell cycle; cell division; cell projection organization; cilium assembly; DNA damage response; kidney development; multicellular organism growth; phosphorylation; protein phosphorylation; regulation of DNA damage checkpoint; response to ionizing radiation; spermatogenesis
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Reference #:
P51954
(UniProtKB)
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Alt. Names/Synonyms: D8Ertd790; D8Ertd790e; kat; kidney, anemia and testis; MGC189817; Nek1; Nek1 serine/threonine- and tyrosine-specific protein kinase; Never in mitosis A-related kinase 1; NIMA (never in mitosis gene a)-related expressed kinase 1; NIMA-related kinase 1; NimA-related protein kinase 1; NY-REN-55 antigen; Serine/threonine-protein kinase Nek1
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Gene Symbols: Nek1
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Molecular weight:
136,690 Da
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Basal Isoelectric point:
5.34
Predict pI for various phosphorylation states
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