NEK1 Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. High fetal expression in the brain and kidney. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8 B3.1|8 30.91 cM
Cellular Component:  centrosome; cytoplasm; cytoskeleton; nucleus; pericentriolar material
Molecular Function:  14-3-3 protein binding; ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; cell cycle; cell division; cell projection organization; cellular response to DNA damage stimulus; cilium assembly; DNA damage response, detection of DNA damage; kidney development; multicellular organism growth; phosphorylation; protein phosphorylation; regulation of DNA damage checkpoint; response to ionizing radiation; signal transduction by protein phosphorylation; spermatogenesis; stress-activated protein kinase signaling cascade
Reference #:  P51954 (UniProtKB)
Alt. Names/Synonyms: D8Ertd790e; kat; kidney, anemia and testis; MGC189817; Nek1; Nek1 serine/threonine- and tyrosine-specific protein kinase; Never in mitosis A-related kinase 1; NIMA (never in mitosis gene a)-related expressed kinase 1; NIMA-related kinase 1; NimA-related protein kinase 1; NY-REN-55 antigen; Serine/threonine-protein kinase Nek1
Gene Symbols: Nek1
Molecular weight: 136,690 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
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NEK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene