NEK1 Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. High fetal expression in the brain and kidney. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 4q33
Cellular Component:  centrosome; cytoplasm; nucleus; pericentriolar material
Molecular Function:  14-3-3 protein binding; ATP binding; kinase activity; metal ion binding; protein binding; protein kinase activity; protein tyrosine kinase activity
Biological Process:  cell cycle; cell division; cilium assembly; DNA damage response, detection of DNA damage; peptidyl-tyrosine phosphorylation; protein phosphorylation
Disease: Amyotrophic Lateral Sclerosis, Susceptibility To, 24; Short-rib Thoracic Dysplasia 6 With Or Without Polydactyly
Reference #:  Q96PY6 (UniProtKB)
Alt. Names/Synonyms: ALS24; DKFZp686D06121; DKFZp686K12169; KIAA1901; MGC138800; NEK1; Never in mitosis A-related kinase 1; NIMA (never in mitosis gene a)-related kinase 1; NIMA related kinase 1; NIMA-related kinase 1; NimA-related protein kinase 1; NY-REN-55; protein-serine/threonine kinase; Renal carcinoma antigen NY-REN-55; Serine/threonine-protein kinase Nek1; SRPS2; SRPS2A; SRTD6
Gene Symbols: NEK1
Molecular weight: 142,828 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein