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NEK1
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. High fetal expression in the brain and kidney. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; NEK family; NEK1 subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 4q33 |
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Cellular Component:
centriolar satellite; centrosome; cytoplasm; cytosol; nucleoplasm; nucleus; pericentriolar material
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Molecular Function:
14-3-3 protein binding; ATP binding; kinase activity; metal ion binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
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Biological Process:
cell cycle; cell division; cilium assembly; protein phosphorylation
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Disease: Amyotrophic Lateral Sclerosis, Susceptibility To, 24; Orofaciodigital Syndrome Ii; Short-rib Thoracic Dysplasia 6 With Or Without Polydactyly
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Reference #:
Q96PY6
(UniProtKB)
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Alt. Names/Synonyms: ALS24; DKFZp686D06121; DKFZp686K12169; KIAA1901; MGC138800; NEK1; Never in mitosis A-related kinase 1; NIMA (never in mitosis gene a)-related kinase 1; NIMA related kinase 1; NIMA-related kinase 1; NimA-related protein kinase 1; NY-REN-55; protein-serine/threonine kinase; Renal carcinoma antigen NY-REN-55; Serine/threonine-protein kinase Nek1; SRPS2; SRPS2A; SRTD6
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Gene Symbols: NEK1
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Molecular weight:
142,828 Da
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Basal Isoelectric point:
5.67
Predict pI for various phosphorylation states
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