GAK Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitous. Highest in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC; GAK subfamily; Kinase, protein; NAK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of rat Ortholog: 14p22
Cellular Component:  cytoplasm; cytosol; focal adhesion; Golgi apparatus; intracellular membrane-bounded organelle; perinuclear region of cytoplasm; vesicle
Molecular Function:  ATP binding; clathrin binding; cyclin binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  clathrin coat assembly; clathrin coat disassembly; clathrin-dependent endocytosis; endoplasmic reticulum organization; epidermal cell differentiation; epithelial cell development; establishment of skin barrier; forebrain morphogenesis; Golgi organization; Golgi to lysosome transport; intrahepatic bile duct development; keratinocyte differentiation; negative regulation of neuron projection development; neural precursor cell proliferation; neuroepithelial cell differentiation; positive regulation of neural precursor cell proliferation; protein localization to Golgi apparatus; protein localization to plasma membrane; protein phosphorylation; receptor-mediated endocytosis; stem cell differentiation
Reference #:  P97874 (UniProtKB)
Alt. Names/Synonyms: cyclin G associated kinase; cyclin G-associated kinase; Cyclin-G-associated kinase; Gak
Gene Symbols: Gak
Molecular weight: 143,703 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene