SDCCAG8
Plays a role in the establishment of cell polarity and epithelial lumen formation. Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis. Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Unknown function |
Chromosomal Location of human Ortholog: 1q43-q44 |
Cellular Component:
cell-cell junction; centriolar satellite; centriole; centrosome; ciliary basal body; cytosol; photoreceptor cell cilium
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Molecular Function:
protein binding
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Biological Process:
cell projection organization; centrosome cycle; establishment of cell polarity; microtubule organizing center organization; neuron migration; regulation of cilium assembly; tube formation
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Disease: Bardet-biedl Syndrome 16; Senior-loken Syndrome 7
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Reference #:
Q86SQ7
(UniProtKB)
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Alt. Names/Synonyms: Antigen NY-CO-8; Bardet-Biedl syndrome 16; BBS16; CCCAP; CCCAP SLSN7; Centrosomal colon cancer autoantigen protein; hCCCAP; HSPC085; nephrocystin 10; NPHP10; NY-CO-8; SDCCAG8; SDCG8; Serologically defined colon cancer antigen 8; SHH signaling and ciliogenesis regulator SDCCAG8; SLSN7
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Gene Symbols: SDCCAG8
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Molecular weight:
82,682 Da
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Basal Isoelectric point:
5.59
Predict pI for various phosphorylation states
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