GAK Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitous. Highest in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC; Kinase, protein; NAK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 4p16.3
Cellular Component:  cytosol; focal adhesion; Golgi apparatus; intracellular membrane-bounded organelle; perinuclear region of cytoplasm; presynapse; vesicle
Molecular Function:  ATP binding; chaperone binding; cyclin binding; protein binding; protein serine/threonine kinase activity
Biological Process:  cell cycle; chaperone cofactor-dependent protein refolding; clathrin coat disassembly; clathrin-coated pit assembly; clathrin-dependent endocytosis; endoplasmic reticulum organization; Golgi organization; Golgi to lysosome transport; membrane organization; negative regulation of neuron projection development; protein localization to Golgi apparatus; protein localization to plasma membrane; protein phosphorylation; receptor-mediated endocytosis; synaptic vesicle uncoating
Reference #:  O14976 (UniProtKB)
Alt. Names/Synonyms: auxilin-2; cyclin G associated kinase; Cyclin-G-associated kinase; DNAJ26; DNAJC26; FLJ16629; FLJ40395; GAK; MGC99654
Gene Symbols: GAK
Molecular weight: 143,191 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB