Haspin Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Haspin family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 11 B4|11 45.25 cM
Cellular Component:  centrosome; chromosome; cytoplasm; cytoskeleton; nucleus; spindle
Molecular Function:  ATP binding; DNA binding; histone kinase activity (H3-T3 specific); kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; chromatin organization; histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; intracellular signal transduction; mitotic cell cycle; mitotic sister chromatid cohesion; negative regulation of G1/S transition of mitotic cell cycle; phosphorylation; protein localization to chromosome, centromeric region; protein phosphorylation
Reference #:  Q9Z0R0 (UniProtKB)
Alt. Names/Synonyms: germ cell associated 2, haspin; germ cell-specific gene 2; Germ cell-specific gene 2 protein; Gsg; Gsg2; Haploid germ cell-specific nuclear protein kinase; HASP; Haspin; histone H3 associated protein kinase; MGC130563; OTTMUSP00000006423; Serine/threonine-protein kinase haspin
Gene Symbols: Haspin
Molecular weight: 84,181 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
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Haspin

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene