Haspin Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Haspin family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component:  centrosome; chromosome; nucleus; spindle
Molecular Function:  ATP binding; histone kinase activity (H3-T3 specific); protein binding; protein kinase activity
Biological Process:  histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; intracellular signal transduction; mitotic sister chromatid cohesion; protein localization to chromosome, centromeric region; protein phosphorylation
Reference #:  Q8TF76 (UniProtKB)
Alt. Names/Synonyms: germ cell associated 2 (haspin); Germ cell-specific gene 2 protein; GSG2; H-haspin; Haploid germ cell-specific nuclear protein kinase; HASP; HASPIN; histone H3 associated protein kinase; Serine/threonine-protein kinase haspin
Gene Symbols: HASPIN
Molecular weight: 88,495 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
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Haspin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein