Haspin Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 2.7.11.1; Haspin family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of human Ortholog: 17p13.2

Cellular Component: centrosome; chromosome; cytoplasm; nucleoplasm; nucleus; spindle

Molecular Function: ATP binding; histone H3T3 kinase activity; protein binding; protein kinase activity; protein serine kinase activity

Biological Process: chromatin remodeling; intracellular signal transduction; mitotic cell cycle; mitotic sister chromatid cohesion; mitotic spindle assembly checkpoint signaling; protein localization to chromosome, centromeric region; protein phosphorylation

Reference #: Q8TF76 (UniProtKB)

Alt. Names/Synonyms: germ cell associated 2 (haspin); germ cell associated 2, haspin; Germ cell-specific gene 2 protein; GSG2; H-haspin; Haploid germ cell-specific nuclear protein kinase; HASP; HASPIN; histone H3 associated protein kinase; Serine/threonine-protein kinase haspin

Gene Symbols: HASPIN

Molecular weight: 88,495 Da

Basal Isoelectric point: 9.32 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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Haspin

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