CAMKK1 a calcium/calmodulin-dependent S/T protein kinase of the CAMKK family. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. 2 isoforms of the human protein are produced by alternative splicing. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. Binding of calmodulin may releave intrasteric autoinhibition. May be regulated through phosphorylation by CAMK1 and CAMK4. Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. Note: This description may include information from UniProtKB.
Protein type: CAMKK family; EC; Kinase, protein; Meta subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10q24
Cellular Component:  cytoplasm; nucleoplasm
Molecular Function:  ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; protein kinase activity; protein serine/threonine kinase activity
Biological Process:  activation of protein kinase activity; intracellular signal transduction; positive regulation of protein kinase activity; protein phosphorylation
Reference #:  P97756 (UniProtKB)
Alt. Names/Synonyms: alpha CaMKK; Calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase 1, alpha; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-kinase IV kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CaM-KK 1; CaM-KK alpha; CaMKK 1; CaMKK alpha; Camkk1; KKCC1
Gene Symbols: Camkk1
Molecular weight: 55,908 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene