CAMKK1 Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMKK family; EC; Kinase, protein; Meta subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 11|11 B4
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; intracellular signal transduction; phosphorylation; positive regulation of protein kinase activity; protein phosphorylation
Reference #:  Q8VBY2 (UniProtKB)
Alt. Names/Synonyms: AI846603; calcium calmodulin dependent protein kinase kinase alpha; Calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase 1, alpha; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-kinase IV kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CaM-KK 1; CaM-KK alpha; Camkk; CaMKK 1; CaMKK alpha; Camkk1; CaMKKalpha; KKCC1; OTTMUSP00000006419
Gene Symbols: Camkk1
Molecular weight: 55,838 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene