RECQL4
DNA-dependent ATPase. May modulate chromosome segregation. Belongs to the helicase family. RecQ subfamily. Ubiquitously expressed, with highest levels in thymus and testis. Note: This description may include information from UniProtKB.
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Protein type: EC 3.6.4.12; Helicase |
Chromosomal Location of human Ortholog: 8q24.3 |
Cellular Component:
chromosome; chromosome, telomeric region; cytoplasm; nucleoplasm; nucleus
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Molecular Function:
3'-5' DNA helicase activity; ATP binding; ATP hydrolysis activity; bubble DNA binding; DNA/DNA annealing activity; four-way junction helicase activity; helicase activity; oxidized purine DNA binding; protein binding; telomeric D-loop binding
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Biological Process:
DNA duplex unwinding; DNA repair; DNA replication; DNA unwinding involved in DNA replication; double-strand break repair via homologous recombination; telomere maintenance; telomeric D-loop disassembly
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Disease: Baller-gerold Syndrome; Rapadilino Syndrome; Rothmund-thomson Syndrome
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Reference #:
O94761
(UniProtKB)
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Alt. Names/Synonyms: ATP-dependent DNA helicase Q4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ helicase-like 4; RecQ like helicase 4; RecQ protein-like 4; RECQ4; RECQL4; RTS
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Gene Symbols: RECQL4
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Molecular weight:
133,067 Da
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Basal Isoelectric point:
8.45
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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