RECQL4 DNA-dependent ATPase. May modulate chromosome segregation. Belongs to the helicase family. RecQ subfamily. Ubiquitously expressed, with highest levels in thymus and testis. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; Helicase
Chromosomal Location of human Ortholog: 8q24.3
Cellular Component:  chromosome, telomeric region
Molecular Function:  annealing helicase activity; ATP binding; ATP-dependent 3'-5' DNA helicase activity; bubble DNA binding; helicase activity; oxidized purine DNA binding; protein binding; telomeric D-loop binding
Biological Process:  DNA duplex unwinding; DNA replication; DNA strand renaturation; multicellular organism development; telomere maintenance; telomeric D-loop disassembly
Disease: Baller-gerold Syndrome; Rapadilino Syndrome; Rothmund-thomson Syndrome
Reference #:  O94761 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent DNA helicase Q4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ helicase-like 4; RecQ like helicase 4; RecQ protein-like 4; RECQ4; RECQL4; RTS
Gene Symbols: RECQL4
Molecular weight: 133,077 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RECQL4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene