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CAMKK1
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMKK family; CAMKK-Meta subfamily; EC 2.7.11.17; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 17p13.2 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm
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Molecular Function:
ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding; protein serine kinase activity
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Biological Process:
intracellular signal transduction; positive regulation of protein kinase activity; protein phosphorylation
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Reference #:
Q8N5S9
(UniProtKB)
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Alt. Names/Synonyms: calcium/calmodulin dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase 1, alpha; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-kinase IV kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CaM-KK 1; CaM-KK alpha; CaMKK 1; CaMKK alpha; CAMKK alpha protein; CAMKK1; CAMKKA; DKFZp761M0423; KKCC1; MGC34095
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Gene Symbols: CAMKK1
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Molecular weight:
55,735 Da
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Basal Isoelectric point:
5.55
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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