CAMKK1 Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMKK family; EC; Kinase, protein; Meta subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 17p13.2
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  ATP binding; protein binding
Biological Process:  protein phosphorylation
Reference #:  Q8N5S9 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase 1, alpha; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-kinase IV kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CaM-KK 1; CaM-KK alpha; CaMKK 1; CaMKK alpha; CAMKK alpha protein; CAMKK1; CAMKKA; DKFZp761M0423; KKCC1; MGC34095
Gene Symbols: CAMKK1
Molecular weight: 55,735 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein