ARSB Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels. Belongs to the sulfatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase
Chromosomal Location of Human Ortholog: 5q14.1
Cellular Component:  azurophil granule lumen; cell surface; endoplasmic reticulum lumen; extracellular region; ficolin-1-rich granule lumen; Golgi apparatus; lysosomal lumen; lysosome; mitochondrion; rough endoplasmic reticulum
Molecular Function:  arylsulfatase activity; metal ion binding; N-acetylgalactosamine-4-sulfatase activity
Biological Process:  autophagy; central nervous system development; chondroitin sulfate catabolic process; colon epithelial cell migration; lysosomal transport; lysosome organization; neutrophil degranulation; positive regulation of neuron projection development; regulation of epithelial cell migration; response to estrogen; response to methylmercury; response to nutrient; response to pH
Disease: Mucopolysaccharidosis Type Vi
Reference #:  P15848 (UniProtKB)
Alt. Names/Synonyms: ARSB; Arylsulfatase B; ASB; G4S; MPS6; N-acetylgalactosamine-4-sulfatase
Gene Symbols: ARSB
Molecular weight: 59,687 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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