CAMKK2 Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; CAMKK family; EC; Kinase, protein; Meta subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component:  cell projection; cytosol; nucleoplasm
Molecular Function:  ATP binding; calcium ion binding; calmodulin binding; calmodulin-dependent protein kinase activity; protein tyrosine kinase activity
Biological Process:  calcium-mediated signaling; CAMKK-AMPK signaling cascade; cellular response to reactive oxygen species; MAPK cascade; peptidyl-tyrosine phosphorylation; positive regulation of autophagy of mitochondrion; positive regulation of protein phosphorylation; positive regulation of transcription, DNA-templated; protein autophosphorylation; protein phosphorylation; regulation of protein kinase activity
Reference #:  Q96RR4 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase beta; Calcium/calmodulin-dependent protein kinase kinase 2; calcium/calmodulin-dependent protein kinase kinase 2, beta; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-kinase kinase 2; CaM-kinase kinase beta; CaM-KK 2; CaM-KK beta; CAMKK; CaMKK 2; CaMKK beta; CAMKK beta protein; CAMKK2; CAMKKB; KIAA0787; KKCC2; MGC15254
Gene Symbols: CAMKK2
Molecular weight: 64,746 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein