PRPK Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. Belongs to the protein kinase superfamily. BUD32 family. Highly expressed in testis. Weakly expressed in heart kidney and spleen. Note: This description may include information from UniProtKB.
Protein type: Bud32 family; EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 2|2 H3
Cellular Component:  cytoplasm; cytosol; EKC/KEOPS complex; nucleus
Molecular Function:  p53 binding; protein serine/threonine kinase activity
Biological Process:  protein phosphorylation; tRNA threonylcarbamoyladenosine metabolic process
Reference #:  Q99PW4 (UniProtKB)
Alt. Names/Synonyms: 2810408M09Rik; 4933401B08Rik; 5630401H01Rik; Atypical serine/threonine protein kinase Tp53rk; EKC/KEOPS complex subunit Tp53rk; EKC/KEOPS complex subunit Tp53rkb; MGC2882; mNo; mNori-2p; Nori-2; Nori-2 protein; OTTMUSP00000017283; p53-related protein kinase; Prpk; TP53 regulating kinase; TP53-regulating kinase; Tp53rk; transformation related protein 53 regulating kinase; transformation related protein 53 regulating kinase B; Trp5; Trp53 regulating kinase; Trp53rk; Trp53rkb; Trp53tk
Gene Symbols: Trp53rkb
Molecular weight: 27,394 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein