PRPK Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. Belongs to the protein kinase superfamily. BUD32 family. Highly expressed in testis. Weakly expressed in heart kidney and spleen. Note: This description may include information from UniProtKB.
Protein type: Bud32 family; EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 20q13.12
Cellular Component:  cytoplasm; cytosol; EKC/KEOPS complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; hydrolase activity; p53 binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  protein phosphorylation; regulation of signal transduction by p53 class mediator; tRNA processing; tRNA threonylcarbamoyladenosine metabolic process
Disease: Galloway-mowat Syndrome 4
Reference #:  Q96S44 (UniProtKB)
Alt. Names/Synonyms: Atypical serine/threonine protein kinase TP53RK; BUD32; C20orf64; dJ101A2; EKC/KEOPS complex subunit TP53RK; GAMOS4; Nori-2; Nori-2p; p53-related protein kinase; PRPK; TP53 regulating kinase; TP53-regulating kinase; TP53RK; TPRKB
Gene Symbols: TP53RK
Molecular weight: 28,160 Da
Basal Isoelectric point: 9.56  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein