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PRPK
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. Belongs to the protein kinase superfamily. BUD32 family. Highly expressed in testis. Weakly expressed in heart kidney and spleen. Note: This description may include information from UniProtKB.
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| Protein type: Bud32 family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 20q13.12 |
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Cellular Component:
cytoplasm; EKC/KEOPS complex; nucleoplasm; nucleus
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Molecular Function:
ATP binding; hydrolase activity; p53 binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
protein phosphorylation; regulation of signal transduction by p53 class mediator; tRNA processing; tRNA threonylcarbamoyladenosine metabolic process
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Disease: Galloway-mowat Syndrome 4
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Reference #:
Q96S44
(UniProtKB)
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Alt. Names/Synonyms: Atypical serine/threonine protein kinase TP53RK; BUD32; C20orf64; dJ101A2; EKC/KEOPS complex subunit TP53RK; GAMOS4; Nori-2; Nori-2p; p53-related protein kinase; PRPK; TP53 regulating kinase; TP53-regulating kinase; TP53RK; TPRKB
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Gene Symbols: TP53RK
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Molecular weight:
28,160 Da
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Basal Isoelectric point:
9.56
Predict pI for various phosphorylation states
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