BUB1B Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily. Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: BUB family; EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 2|2 E5
Cellular Component:  chromosome; chromosome, centromeric region; condensed chromosome kinetochore; condensed chromosome outer kinetochore; condensed nuclear chromosome kinetochore; cytoplasm; cytosol; kinetochore; nucleus; perinuclear region of cytoplasm; spindle
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  apoptotic process; cell cycle; cell division; meiotic sister chromatid cohesion, centromeric; metaphase/anaphase transition of mitotic cell cycle; mitotic spindle assembly checkpoint; phosphorylation; protein localization to chromosome, centromeric region
Reference #:  Q9Z1S0 (UniProtKB)
Alt. Names/Synonyms: AU045529; Bub1b; BUB1B, mitotic checkpoint serine/threonine kinase; BUBR; BubR1; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog, beta; budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae); MAD3/BUB1-related protein kinase; Mad3l; MGC36092; Mitotic checkpoint kinase MAD3L; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; OTTMUSP00000016369
Gene Symbols: Bub1b
Molecular weight: 118,392 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene