ADAMTS3 Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens. Found in cartilage and skin. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component:  extracellular matrix; extracellular region; extracellular space
Molecular Function:  endopeptidase activity; heparin binding; metalloendopeptidase activity; protein binding; zinc ion binding
Biological Process:  collagen biosynthetic process; collagen catabolic process; collagen fibril organization; positive regulation of vascular endothelial growth factor signaling pathway; protein processing; supramolecular fiber organization; vascular endothelial growth factor production
Disease: Hennekam Lymphangiectasia-lymphedema Syndrome 3
Reference #:  O15072 (UniProtKB)
Alt. Names/Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 3; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3; ADAM metallopeptidase with thrombospondin type 1 motif 3; ADAM metallopeptidase with thrombospondin type 1 motif, 3; ADAM-TS 3; ADAM-TS3; ADAMTS-3; ADAMTS-4; ADAMTS3; ATS3; HKLLS3; KIAA0366; PC II-NP; Procollagen II amino propeptide-processing enzyme; Procollagen II N-proteinase; zinc metalloendopeptidase
Gene Symbols: ADAMTS3
Molecular weight: 135,603 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene