AurA a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595. Note: This description may include information from UniProtKB.
Protein type: AUR family; EC; Kinase, protein; Oncoprotein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3q42
Cellular Component:  axon hillock; centriole; centrosome; chromosome passenger complex; cilium; condensed nuclear chromosome, centromeric region; cytosol; germinal vesicle; meiotic spindle; microtubule cytoskeleton; microtubule organizing center; mitotic spindle; mitotic spindle pole; nucleus; perinuclear region of cytoplasm; pronucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome
Molecular Function:  ATP binding; histone serine kinase activity; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; ubiquitin protein ligase binding
Biological Process:  anterior/posterior axis specification; cell division; cell projection organization; centrosome cycle; centrosome localization; histone-serine phosphorylation; liver regeneration; meiotic cell cycle; meiotic spindle organization; microtubule cytoskeleton organization; mitotic cell cycle; mitotic centrosome separation; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of protein binding; neuron projection extension; positive regulation of meiotic cell cycle process involved in oocyte maturation; positive regulation of oocyte maturation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of translation; protein localization to centrosome; protein phosphorylation; regulation of cytokinesis; regulation of protein stability; response to estradiol; response to wounding; spindle assembly involved in female meiosis I; spindle organization
Reference #:  P59241 (UniProtKB)
Alt. Names/Synonyms: Aurka; Aurora A; Aurora kinase A; aurora-A; MGC124935; ratAurA; serine/threonine kinase 6; serine/threonine protein kinase 6; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Stk15; Stk6
Gene Symbols: Aurka
Molecular weight: 44,874 Da
Basal Isoelectric point: 9.48  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene