AurA
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Note: This description may include information from UniProtKB.
Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Oncoprotein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: ATP binding; histone H3S10 kinase activity; molecular function activator activity; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process: anterior/posterior axis specification; apoptotic process; cell division; centrosome localization; chromatin remodeling; cilium disassembly; G2/M transition of mitotic cell cycle; liver regeneration; mitotic cell cycle; mitotic centrosome separation; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of protein binding; neuron projection extension; peptidyl-serine phosphorylation; positive regulation of mitochondrial fission; positive regulation of mitotic cell cycle; positive regulation of mitotic nuclear division; positive regulation of oocyte maturation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein localization to centrosome; protein phosphorylation; regulation of centrosome cycle; regulation of cytokinesis; regulation of G2/M transition of mitotic cell cycle; regulation of protein stability; regulation of signal transduction by p53 class mediator; response to wounding; spindle assembly involved in female meiosis I; spindle organization
