AurB Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 11 B3|11 42.32 cM
Cellular Component:  chromocenter; chromosome; chromosome passenger complex; chromosome, centromeric region; condensed chromosome, centromeric region; condensed nuclear chromosome, centromeric region; cytoplasm; cytoskeleton; kinetochore; midbody; mitotic spindle midzone; mitotic spindle pole; nucleoplasm; nucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome
Molecular Function:  ATP binding; histone serine kinase activity; kinase activity; kinase binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell division; cellular response to UV; cleavage furrow formation; histone H3-S28 phosphorylation; mitotic spindle assembly checkpoint; mitotic spindle midzone assembly; mitotic spindle organization; negative regulation of B cell apoptotic process; negative regulation of protein binding; negative regulation of transcription by RNA polymerase II; phosphorylation; positive regulation of cytokinesis; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein localization to kinetochore; protein phosphorylation; regulation of cytokinesis; spindle organization
Reference #:  O70126 (UniProtKB)
Alt. Names/Synonyms: Aik2; AIM-1; Aim1; AIRK2; AL022959; ARK-2; Ark2; AurB; Aurkb; Aurora B; Aurora kinase B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; OTTMUSP00000006162; OTTMUSP00000006163; serine/threonine kinase 12; serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; STK-1; Stk1; Stk12; Stk5
Gene Symbols: Aurkb
Molecular weight: 39,384 Da
Basal Isoelectric point: 9.47  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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AurB

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene