MINK Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; MSN subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 11|11 B3
Cellular Component:  cell junction; cell projection; cytoplasm; Golgi apparatus; membrane; plasma membrane; postsynaptic membrane; synapse
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  actin cytoskeleton reorganization; activation of protein kinase activity; chemical synaptic transmission; dendrite morphogenesis; MAPK cascade; multicellular organism development; negative thymic T cell selection; neuron cellular homeostasis; neuron projection morphogenesis; phosphorylation; positive regulation of JNK cascade; positive regulation of p38MAPK cascade; protein autophosphorylation; protein phosphorylation; regulation of AMPA receptor activity; regulation of cell migration; regulation of cell-cell adhesion; regulation of cell-matrix adhesion; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q9JM52 (UniProtKB)
Alt. Names/Synonyms: B55; GCK family kinase MiNK; Map4k6; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Mink; Mink1; Misshapen-like kinase 1; misshapen-like kinase 1 (zebrafish); Misshapen/NIK-related kinase; Misshapen/NIKs-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6; OTTMUSP00000006326; OTTMUSP00000006327; OTTMUSP00000006328; RP23-122P1.6; Yeast Sps1/Ste20-related kinase 2; Ysk2
Gene Symbols: Mink1
Molecular weight: 147,295 Da
Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein