SERCA2 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; EC; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 12q16
Cellular Component:  apical ectoplasmic specialization; calcium ion-transporting ATPase complex; endoplasmic reticulum; endoplasmic reticulum membrane; extrinsic component of cytoplasmic side of plasma membrane; integral component of membrane; longitudinal sarcoplasmic reticulum; membrane; nucleoplasm; perinuclear region of cytoplasm; plasma membrane bounded cell projection; protein-containing complex; ribbon synapse; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; vesicle membrane
Molecular Function:  ATP binding; calcium ion binding; calcium-transporting ATPase activity; calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential; enzyme binding; lutropin-choriogonadotropic hormone receptor binding; protein binding; protein C-terminus binding; proton-exporting ATPase activity, phosphorylative mechanism; S100 protein binding
Biological Process:  ATP hydrolysis coupled cation transmembrane transport; calcium ion import into sarcoplasmic reticulum; calcium ion transmembrane transport; calcium ion transport; calcium ion transport from cytosol to endoplasmic reticulum; cardiac muscle hypertrophy in response to stress; cellular calcium ion homeostasis; cellular response to heat; cellular response to oxidative stress; endoplasmic reticulum calcium ion homeostasis; ER-nucleus signaling pathway; negative regulation of heart contraction; organelle organization; positive regulation of endoplasmic reticulum calcium ion concentration; proton transmembrane transport; regulation of calcium ion-dependent exocytosis of neurotransmitter; regulation of cardiac muscle cell action potential involved in regulation of contraction; regulation of cardiac muscle cell membrane potential; regulation of cardiac muscle contraction by calcium ion signaling; regulation of muscle contraction; regulation of the force of heart contraction; relaxation of cardiac muscle; response to endoplasmic reticulum stress; response to lipopolysaccharide; response to peptide hormone; sarcoplasmic reticulum calcium ion transport; skeletal muscle contraction; T-tubule organization; transition between fast and slow fiber
Reference #:  P11507 (UniProtKB)
Alt. Names/Synonyms: AT2A2; Atp2a2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SercaII; SR Ca(2+)-ATPase 2
Gene Symbols: Atp2a2
Molecular weight: 114,768 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene