TEAD1 Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of rat Ortholog: 1q33
Cellular Component:  nucleoplasm; nucleus; TEAD-1-YAP complex; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; proximal promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription coactivator binding; transcription regulator recruiting activity; transcription regulatory region DNA binding
Biological Process:  cellular response to retinoic acid; embryonic heart tube morphogenesis; heart development; hippo signaling; lateral mesoderm development; notochord development; paraxial mesoderm development; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of protein serine/threonine kinase activity; positive regulation of stem cell population maintenance; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein-containing complex assembly; regulation of cell proliferation; regulation of gene expression; regulation of transcription, DNA-templated; transition between fast and slow fiber
Reference #:  NP_001185518 (RefSeq)
Alt. Names/Synonyms: TEA domain family member 1; Tead1; TEF-1; TEF-1 epsilon; transcriptional enhancer factor TEF-1
Gene Symbols: Tead1
Molecular weight: 46,759 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene