SERCA2 an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. Possesses a Ca(2+)-ATPase activity. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; EC; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 5 62.38 cM|5 F
Cellular Component:  apical ectoplasmic specialization; calcium ion-transporting ATPase complex; endoplasmic reticulum; endoplasmic reticulum membrane; extrinsic component of cytoplasmic side of plasma membrane; integral component of membrane; longitudinal sarcoplasmic reticulum; membrane; nucleoplasm; perinuclear region of cytoplasm; plasma membrane bounded cell projection; protein-containing complex; ribbon synapse; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; vesicle membrane
Molecular Function:  ATP binding; calcium ion binding; calcium-transporting ATPase activity; calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential; enzyme binding; lutropin-choriogonadotropic hormone receptor binding; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; proton-exporting ATPase activity, phosphorylative mechanism; S100 protein binding
Biological Process:  calcium ion import into sarcoplasmic reticulum; calcium ion transmembrane transport; calcium ion transport; calcium ion transport from cytosol to endoplasmic reticulum; cardiac muscle hypertrophy in response to stress; cellular calcium ion homeostasis; cellular response to oxidative stress; endoplasmic reticulum calcium ion homeostasis; ER-nucleus signaling pathway; ion transport; negative regulation of heart contraction; organelle organization; positive regulation of endoplasmic reticulum calcium ion concentration; regulation of calcium ion-dependent exocytosis of neurotransmitter; regulation of cardiac muscle cell action potential involved in regulation of contraction; regulation of cardiac muscle cell membrane potential; regulation of cardiac muscle contraction by calcium ion signaling; regulation of muscle contraction; regulation of the force of heart contraction; relaxation of cardiac muscle; response to peptide hormone; sarcoplasmic reticulum calcium ion transport; T-tubule organization; transition between fast and slow fiber
Reference #:  O55143 (UniProtKB)
Alt. Names/Synonyms: 9530097L16Rik; AT2A2; Atp2a2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; D5Wsu150e; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; KIAA4195; mKIAA4195; sarco/endoplasmic reticulum Ca2+-ATPase 2; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2
Gene Symbols: Atp2a2
Molecular weight: 114,858 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene