SLC34A1 Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. Belongs to the SLC34A transporter family. Kidney and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of mouse Ortholog: 13 B1|13 29.81 cM
Cellular Component:  apical plasma membrane; basolateral plasma membrane; brush border; brush border membrane; cell surface; endosome; integral component of membrane; intrinsic component of plasma membrane; membrane; membrane raft; mitotic spindle; nuclear speck; perinuclear region of cytoplasm; plasma membrane; vesicle
Molecular Function:  PDZ domain binding; protein binding; protein homodimerization activity; protein-containing complex binding; sodium-dependent phosphate transmembrane transporter activity; sodium:phosphate symporter activity; symporter activity
Biological Process:  arsenate ion transmembrane transport; bone remodeling; cellular phosphate ion homeostasis; ion transport; phosphate ion homeostasis; phosphate ion transmembrane transport; phosphate ion transport; positive regulation of membrane potential; positive regulation of phosphate transmembrane transport; positive regulation of sodium-dependent phosphate transport; protein homooligomerization; response to cadmium ion; response to lead ion; response to mercury ion; sodium ion import across plasma membrane; sodium ion transport; sodium-dependent phosphate transport
Reference #:  Q60825 (UniProtKB)
Alt. Names/Synonyms: Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; Na+-phosphate cotransporter type II; Na/Pi cotransporter; NaPi-2a; NaPi-7; NaPi-IIa; Npt2; Npt2a; renal Na+/Pi transporter; Slc1; Slc17a2; Slc34a1; Sodium-dependent phosphate transport protein 2A; Sodium-phosphate transport protein 2A; Sodium/phosphate cotransporter 2A; solute carrier family 17 (sodium/hydrogen exchanger), member 2; solute carrier family 34 (sodium phosphate), member 1; Solute carrier family 34 member 1; type IIa Na+/Pi-cotransporter
Gene Symbols: Slc34a1
Molecular weight: 68,774 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene