SLC34A1 Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. Belongs to the SLC34A transporter family. Kidney and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 5q35.3
Cellular Component:  apical plasma membrane; brush border membrane; cell surface; endosome; integral component of plasma membrane; membrane raft; mitotic spindle; nuclear speck; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  PDZ domain binding; protein binding; protein homodimerization activity; protein-containing complex binding; sodium-dependent phosphate transmembrane transporter activity
Biological Process:  arsenate ion transmembrane transport; cellular protein metabolic process; cellular response to metal ion; cellular response to parathyroid hormone stimulus; cellular response to staurosporine; dentinogenesis; gentamycin metabolic process; glycoprotein metabolic process; indole metabolic process; kidney development; ossification; phosphate ion homeostasis; phosphate ion transmembrane transport; phosphate ion transport; positive regulation of membrane potential; positive regulation of phosphate transmembrane transport; positive regulation of sodium-dependent phosphate transport; protein homooligomerization; response to cadmium ion; response to drug; response to estradiol; response to growth hormone; response to lead ion; response to magnesium ion; response to mercury ion; response to potassium ion; response to thyroid hormone; response to vitamin A; sodium ion import across plasma membrane; tricarboxylic acid metabolic process
Disease: Fanconi Renotubular Syndrome 2; Hypercalcemia, Infantile, 2; Nephrolithiasis/osteoporosis, Hypophosphatemic, 1
Reference #:  Q06495 (UniProtKB)
Alt. Names/Synonyms: FRTS2; HCINF2; Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; Na+-phosphate cotransporter type II; NaPi-2a; NaPi-3; NPHLOP1; NPT2; NPT2A; NPTIIa; renal sodium-dependent phosphate transporter; SLC11; SLC17A2; SLC34A1; Sodium-dependent phosphate transport protein 2A; Sodium-phosphate transport protein 2A; sodium/phosphate co-transporter; Sodium/phosphate cotransporter 2A; solute carrier family 17 (sodium phosphate), member 2; solute carrier family 34 (sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate cotransporter), member 1; Solute carrier family 34 member 1
Gene Symbols: SLC34A1
Molecular weight: 68,937 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene