|
VDAC1
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Belongs to the eukaryotic mitochondrial porin family. Heart, liver and skeletal muscle. Note: This description may include information from UniProtKB.
|
| Protein type: Channel, misc.; Membrane protein, integral; Mitochondrial |
| Chromosomal Location of rat Ortholog: 10q22 |
|
Cellular Component:
membrane; membrane raft; mitochondrial membrane; mitochondrial nucleoid; mitochondrial outer membrane; mitochondrial permeability transition pore complex; mitochondrion; plasma membrane; pore complex; postsynaptic density membrane; presynaptic active zone membrane; protein-containing complex; synapse; synaptic vesicle
|
|
Molecular Function:
calcium channel activity; ceramide binding; cholesterol binding; identical protein binding; monoatomic anion channel activity; nucleotide binding; phosphatidylcholine binding; porin activity; protein binding; protein kinase binding; protein-containing complex binding; transmembrane transporter binding; voltage-gated monoatomic anion channel activity
|
|
Biological Process:
apoptotic process; behavioral fear response; chemical synaptic transmission; epithelial cell differentiation; learning; mitochondrial calcium ion transmembrane transport; monoatomic anion transmembrane transport; monoatomic anion transport; negative regulation of apoptotic process; negative regulation of calcium import into the mitochondrion; negative regulation of reactive oxygen species metabolic process; neuron-neuron synaptic transmission; positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; regulation of autophagy of mitochondrion
|
|
Reference #:
Q9Z2L0
(UniProtKB)
|
|
Alt. Names/Synonyms: Outer mitochondrial membrane protein porin 1; rVDAC1; VDAC-1; Vdac1; voltage-dependent anion channel 1; Voltage-dependent anion-selective channel protein 1
|
|
Gene Symbols: Vdac1
|
|
Molecular weight:
30,756 Da
|
|
Basal Isoelectric point:
8.62
Predict pI for various phosphorylation states
|
|
CST Pathways:
Warburg Effect
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
