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ID1
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 20q11.21 |
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Cellular Component:
Golgi apparatus; nucleoplasm; nucleus
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Molecular Function:
protein binding; protein dimerization activity; transcription regulator activity; transcription regulator inhibitor activity
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Biological Process:
angiogenesis; blood vessel endothelial cell migration; blood vessel morphogenesis; cell differentiation; circadian regulation of gene expression; negative regulation of cold-induced thermogenesis; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; negative regulation of transcription by transcription factor localization; transforming growth factor beta receptor signaling pathway
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Reference #:
P41134
(UniProtKB)
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Alt. Names/Synonyms: BHLHB24; Class B basic helix-loop-helix protein 24; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein); DNA-binding protein inhibitor ID-1; ID; ID1; inhibitor of differentiation 1; Inhibitor of DNA binding 1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; inhibitor of DNA binding 1, HLH protein
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Gene Symbols: ID1
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Molecular weight:
16,133 Da
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Basal Isoelectric point:
6.57
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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