mAChR M3
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily. Note: This description may include information from UniProtKB.
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Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
Chromosomal Location of human Ortholog: 1q43 |
Cellular Component:
basal plasma membrane; basolateral plasma membrane; dendrite; endoplasmic reticulum membrane; plasma membrane; postsynaptic membrane; synapse
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Molecular Function:
acetylcholine binding; G protein-coupled acetylcholine receptor activity; G protein-coupled serotonin receptor activity; phosphatidylinositol phospholipase C activity; protein binding; signaling receptor activity
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Biological Process:
acetylcholine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; calcium-mediated signaling; chemical synaptic transmission; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G protein-coupled serotonin receptor signaling pathway; ion channel modulating, G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; nervous system development; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; positive regulation of insulin secretion; positive regulation of smooth muscle contraction; protein modification process; regulation of monoatomic ion transmembrane transporter activity; regulation of vascular associated smooth muscle contraction; saliva secretion; signal transduction; smooth muscle contraction; synaptic transmission, cholinergic
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Disease: Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism
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Reference #:
P20309
(UniProtKB)
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Alt. Names/Synonyms: acetylcholine receptor, muscarinic 3; ACM3; cholinergic receptor muscarinic 3; cholinergic receptor, muscarinic 3; CHRM3; EGBRS; HM3; m3 muscarinic receptor; mAChR M3; Muscarinic acetylcholine receptor M3; Muscarinic M3 Acetylcholine Receptor; PBS
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Gene Symbols: CHRM3
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Molecular weight:
66,128 Da
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Basal Isoelectric point:
9.33
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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