STEP
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor) |
Chromosomal Location of rat Ortholog: 1q22 |
Cellular Component:
axon; cell junction; cytosol; neuronal cell body; perikaryon; plasma membrane; proximal dendrite; synaptic membrane; synaptic vesicle
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Molecular Function:
identical protein binding; phosphotyrosine residue binding; protein kinase binding; protein tyrosine phosphatase activity
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Biological Process:
exploration behavior; negative regulation of MAP kinase activity; peptidyl-tyrosine dephosphorylation; positive regulation of long-term synaptic potentiation; positive regulation of neuron projection development; positive regulation of protein import into nucleus; positive regulation of protein phosphorylation; positive regulation of protein targeting to mitochondrion; positive regulation of receptor internalization; positive regulation of response to drug; protein dephosphorylation; regulation of neuron apoptotic process; response to amphetamine; response to immobilization stress; response to xenobiotic stimulus; signal transduction
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Reference #:
P35234
(UniProtKB)
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Alt. Names/Synonyms: Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5; protein-tyrosine phosphatase striatum-enriched; protein-tyrosine-phosphatase non-receptor 5; PTN5; Ptpn5; STEP; Striatum-enriched protein-tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 5
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Gene Symbols: Ptpn5
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Molecular weight:
42,366 Da
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Basal Isoelectric point:
5
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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