STEP May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 1q22
Cellular Component:  axon; cytosol; endoplasmic reticulum; membrane; neuronal cell body; perikaryon; proximal dendrite; synaptic membrane; synaptic vesicle
Molecular Function:  glutamate receptor binding; mitogen-activated protein kinase binding; phosphotyrosine residue binding; protein homodimerization activity; protein kinase binding; protein tyrosine phosphatase activity
Biological Process:  aging; exploration behavior; negative regulation of MAP kinase activity; peptidyl-tyrosine dephosphorylation; positive regulation of long-term synaptic potentiation; positive regulation of neuron death; positive regulation of neuron projection development; positive regulation of protein phosphorylation; positive regulation of protein targeting to mitochondrion; positive regulation of receptor internalization; positive regulation of response to drug; protein dephosphorylation; response to acetylsalicylate; response to amphetamine; response to drug; response to immobilization stress
Reference #:  P35234 (UniProtKB)
Alt. Names/Synonyms: Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5; protein-tyrosine phosphatase striatum-enriched; protein-tyrosine-phosphatase non-receptor 5; PTN5; Ptpn5; STEP; Striatum-enriched protein-tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 5
Gene Symbols: Ptpn5
Molecular weight: 42,366 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene