CYP2B6 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. Belongs to the cytochrome P450 family. Expressed in liver, lung and heart right ventricle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC; Lipid Metabolism - arachidonic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bounded organelle
Molecular Function:  arachidonic acid epoxygenase activity; aromatase activity; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity
Biological Process:  epoxygenase P450 pathway; exogenous drug catabolic process; organic acid metabolic process; oxidation-reduction process; xenobiotic metabolic process
Reference #:  P00176 (UniProtKB)
Alt. Names/Synonyms: CP2B1; Cyp2b-1; Cyp2b1; CYP2B1; Cyp2b12; CYP2B6; CYPIIB1; CYPIIB12; cytochrome P-450b type b; Cytochrome P450 2B1; cytochrome P450 2B12; cytochrome P450, family 2, subfamily b, polypeptide 12; Cytochrome P450-B; Cytochrome P450-LM2; Cytochrome P450-PB1; Cytochrome P450-PB2; Cytochrome P450b
Gene Symbols: Cyp2b1
Molecular weight: 55,934 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene