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E2F7
Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. Belongs to the E2F/DP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 12q21.2 |
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Cellular Component:
chromatin; nuclear speck; nucleoplasm; RNA polymerase II transcription regulator complex
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Molecular Function:
cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
chorionic trophoblast cell differentiation; DNA damage response, signal transduction by p53 class mediator; hepatocyte differentiation; negative regulation of cell population proliferation; negative regulation of cytokinesis; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; placenta development; positive regulation of DNA endoreduplication; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; sprouting angiogenesis; trophoblast giant cell differentiation
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Reference #:
Q96AV8
(UniProtKB)
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Alt. Names/Synonyms: E2F transcription factor 7; E2F-7; E2F7; FLJ12981; Transcription factor E2F7
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Gene Symbols: E2F7
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Molecular weight:
99,888 Da
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Basal Isoelectric point:
8.33
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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G1/S Checkpoint
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