SMURF1 E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Plays a role in dendrite formation by melanocytes. Expressed in melanocytes (PubMed:23999003). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 7q22.1
Cellular Component:  axon; cytoplasm; cytosol; neuronal cell body; nucleoplasm; plasma membrane
Molecular Function:  activin binding; I-SMAD binding; phospholipid binding; protein binding; R-SMAD binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  BMP signaling pathway; cell differentiation; ectoderm development; engulfment of target by autophagosome; negative regulation of BMP signaling pathway; negative regulation of ossification; negative regulation of transforming growth factor beta receptor signaling pathway; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; positive regulation of dendrite extension; positive regulation of ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein export from nucleus; protein localization to cell surface; protein localization to plasma membrane; protein polyubiquitination; protein targeting to vacuole involved in autophagy; protein ubiquitination; receptor catabolic process; substrate localization to autophagosome; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process; ubiquitin-dependent SMAD protein catabolic process; Wnt signaling pathway, planar cell polarity pathway
Reference #:  Q9HCE7 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin ligase SMURF1; E3 ubiquitin-protein ligase SMURF1; HECT-type E3 ubiquitin transferase SMURF1; hSMURF1; KIAA1625; SMAD specific E3 ubiquitin protein ligase 1; SMAD ubiquitination regulatory factor 1; Smad-specific E3 ubiquitin ligase 1; SMAD-specific E3 ubiquitin-protein ligase 1; SMUF1; SMURF1
Gene Symbols: SMURF1
Molecular weight: 86,114 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
CST Pathways:  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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