Lamin B1 nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 18 D3|18 30.84 cM
Cellular Component:  cytoplasm; intermediate filament; lamin filament; membrane; nuclear envelope; nuclear inner membrane; nuclear lamina; nuclear matrix; nuclear membrane; nucleoplasm; nucleus
Molecular Function:  double-stranded DNA binding; JUN kinase binding; phospholipase binding; sequence-specific double-stranded DNA binding; structural molecule activity
Biological Process:  cellular response to monosodium L-glutamate; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of JNK cascade
Reference #:  P14733 (UniProtKB)
Alt. Names/Synonyms: lamin B1; Lamin-B1; Lmnb1; OTTMUSP00000017522
Gene Symbols: Lmnb1
Molecular weight: 66,786 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Lamin B1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene