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Lamin B1
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of human Ortholog: 5q23.2 |
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Cellular Component:
lamin filament; nuclear envelope; nuclear inner membrane; nuclear lamina; nuclear matrix; nuclear membrane; nucleoplasm; nucleus
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Molecular Function:
phospholipase binding; protein binding; sequence-specific double-stranded DNA binding; structural constituent of cytoskeleton; structural molecule activity
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Biological Process:
cytoskeleton organization; heterochromatin formation; nuclear envelope organization; nuclear migration; nuclear pore localization; protein localization to nuclear envelope
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Disease: Microcephaly 26, Primary, Autosomal Dominant
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Reference #:
P20700
(UniProtKB)
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Alt. Names/Synonyms: ADLD; lamin B1; Lamin-B1; LMN; LMN2; LMNB; LMNB1; MGC111419
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Gene Symbols: LMNB1
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Molecular weight:
66,408 Da
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Basal Isoelectric point:
5.11
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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