Lamin B1 Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of human Ortholog: 5q23.2
Cellular Component:  lamin filament; nuclear envelope; nuclear inner membrane; nuclear matrix; nuclear membrane; nucleoplasm; nucleus
Molecular Function:  phospholipase binding; protein binding; sequence-specific double-stranded DNA binding; structural molecule activity
Biological Process:  interleukin-12-mediated signaling pathway
Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant; Microcephaly 26, Primary, Autosomal Dominant
Reference #:  P20700 (UniProtKB)
Alt. Names/Synonyms: ADLD; lamin B1; Lamin-B1; LMN; LMN2; LMNB; LMNB1; MGC111419
Gene Symbols: LMNB1
Molecular weight: 66,408 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Lamin B1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene