NHEDC2 Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 4q24
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cell junction; endosome membrane; integral component of membrane; mitochondrial inner membrane; mitochondrial membrane; plasma membrane; sperm principal piece; synaptic vesicle membrane
Molecular Function:  identical protein binding; lithium:proton antiporter activity; monovalent cation:proton antiporter activity; sodium:proton antiporter activity
Biological Process:  clathrin-dependent endocytosis; flagellated sperm motility; ion transmembrane transport; positive regulation of osteoclast development; proton transmembrane transport; regulation of insulin secretion involved in cellular response to glucose stimulus; sodium ion transmembrane transport; sodium ion transport
Reference #:  Q86UD5 (UniProtKB)
Alt. Names/Synonyms: FLJ23984; Mitochondrial Na(+)/H(+) exchanger NHA2; Mitochondrial sodium/hydrogen exchanger NHA2; Na(+)/H(+) exchanger-like domain-containing protein 2; Na+/H+ exchanger domain containing 2; NHA2; NHDC2; NHE domain-containing protein 2; NHE10; NHEDC2; Sodium/hydrogen exchanger 9B2; Sodium/hydrogen exchanger-like domain-containing protein 2
Gene Symbols: SLC9B2
Molecular weight: 57,564 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene