GRK3 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Note: This description may include information from UniProtKB.
Protein type: AGC group; BARK subfamily; EC 2.7.11.15; GRK family; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q16
Cellular Component:  axon; cilium; cytosol; dendrite terminus; dendritic shaft; dendritic spine; membrane; membrane raft; nucleus; perinuclear region of cytoplasm; sperm midpiece; synapse; Z disc
Molecular Function:  ATP binding; beta-adrenergic receptor kinase activity; D1 dopamine receptor binding; G protein-coupled receptor kinase activity; protein serine/threonine kinase activity
Biological Process:  desensitization of G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; inositol phosphate metabolic process; intracellular protein transport; multicellular organism aging; negative regulation of G protein-coupled receptor signaling pathway; positive regulation of protein phosphorylation; protein phosphorylation; receptor internalization; response to morphine; rhodopsin metabolic process; signal transduction
Reference #:  P26819 (UniProtKB)
Alt. Names/Synonyms: Adrbk2; adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase); adrenergic, beta, receptor kinase 2; ARBK2; beta ARK2; Beta-adrenergic receptor kinase 2; Beta-ARK-2; G-protein-coupled receptor kinase 3; Grk3
Gene Symbols: Grk3
Molecular weight: 79,887 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Select Structure to View Below

GRK3

Protein Structure Not Found.

Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene