GRK3 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Note: This description may include information from UniProtKB.
Protein type: AGC group; BARK subfamily; EC; GRK family; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 22q12.1
Cellular Component:  cytosol; plasma membrane
Molecular Function:  ATP binding; beta-adrenergic receptor kinase activity; G protein-coupled receptor kinase activity; protein kinase activity
Biological Process:  G protein-coupled receptor signaling pathway; protein phosphorylation; receptor internalization; signal transduction
Reference #:  P35626 (UniProtKB)
Alt. Names/Synonyms: ADRBK2; adrenergic, beta, receptor kinase 2; ARBK2; BARK2; Beta-adrenergic receptor kinase 2; Beta-ARK-2; G-protein-coupled receptor kinase 3; GRK3
Gene Symbols: GRK3
Molecular weight: 79,710 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB