Spinophilin Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component:  adherens junction; cytoplasm; dendritic spine; filopodium; lamellipodium; nucleoplasm; plasma membrane; protein phosphatase type 1 complex; ruffle membrane
Molecular Function:  protein binding; protein phosphatase 1 binding; protein phosphatase inhibitor activity
Biological Process:  cell cycle arrest; cell migration; cellular response to morphine; filopodium assembly; modulation of chemical synaptic transmission; negative regulation of cell growth; negative regulation of phosphoprotein phosphatase activity; regulation of cell growth by extracellular stimulus; regulation of cell proliferation; regulation of exit from mitosis; regulation of opioid receptor signaling pathway; RNA splicing
Reference #:  Q96SB3 (UniProtKB)
Alt. Names/Synonyms: FLJ30345; NEB2; neurabin II; Neurabin-2; Neurabin-II; PPP1R6; PPP1R9; PPP1R9B; Protein phosphatase 1 regulatory subunit 9B; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin; SPINO; Spinophilin; SPL; Spn
Gene Symbols: PPP1R9B
Molecular weight: 89,334 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Spinophilin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene