SLC25A25
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Belongs to the mitochondrial carrier (TC 2.A.29) family. Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues tested. Isoform 2 expression is restricted to kidney and lung. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family |
Chromosomal Location of mouse Ortholog: 2|2 B |
Cellular Component:
membrane; mitochondrial inner membrane; mitochondrion
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Molecular Function:
antiporter activity; ATP transmembrane transporter activity; ATP:inorganic phosphate antiporter activity; calcium ion binding; metal ion binding
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Biological Process:
adipose tissue development; ADP transport; ATP metabolic process; ATP transport; calcium ion transmembrane transport; camera-type eye development; cellular respiration; multicellular organism growth; response to activity; response to dietary excess; response to food; transmembrane transport
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Reference #:
A2ASZ8
(UniProtKB)
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Alt. Names/Synonyms: 1110030N17Rik; Calcium-binding mitochondrial carrier protein SCaMC-2; Kiaa1896; MCSC; MGC36388; Mitochondrial adenyl nucleotide antiporter SLC25A25; mitochondrial Ca2+-dependent solute carrier; mKIAA1896; OTTMUSP00000012866; Scamc2; SCMC2; Slc25a25; Small calcium-binding mitochondrial carrier protein 2; solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25; Solute carrier family 25 member 25
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Gene Symbols: Slc25a25
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Molecular weight:
52,621 Da
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Basal Isoelectric point:
8.75
Predict pI for various phosphorylation states
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