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ATAT1
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. Belongs to the acetyltransferase ATAT1 family. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase; EC 2.3.1.108 |
| Chromosomal Location of human Ortholog: 6p21.33 |
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Cellular Component:
axon; clathrin-coated pit; cytosol; focal adhesion; Golgi apparatus; microtubule; microtubule bundle; mitotic spindle
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Molecular Function:
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; tubulin N-acetyltransferase activity
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Biological Process:
alpha-tubulin acetylation; cilium assembly; dentate gyrus development; microtubule cytoskeleton organization; neuron development; NLRP3 inflammasome complex assembly; positive regulation of NLRP3 inflammasome complex assembly; regulation of fat cell differentiation; regulation of microtubule cytoskeleton organization; response to mechanical stimulus; response to pain; spermatogenesis
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Reference #:
Q5SQI0
(UniProtKB)
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Alt. Names/Synonyms: Acetyltransferase mec-17 homolog; alpha tubulin acetyltransferase 1; Alpha-TAT; Alpha-TAT1; alpha-tubulin N-acetyltransferase; Alpha-tubulin N-acetyltransferase 1; ATAT; ATAT1; C6orf134; CF134; chromosome 6 open reading frame 134; DKFZp547J097; FLJ13158; LOC79969; MEC-17; MEC17; Nbla00487; TAT; UPF0635 protein C6orf134
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Gene Symbols: ATAT1
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Molecular weight:
46,810 Da
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Basal Isoelectric point:
9.97
Predict pI for various phosphorylation states
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