ALDH8A1 Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. Belongs to the aldehyde dehydrogenase family. Highly expressed in adult kidney and liver. Detected at lower levels in fetal liver and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.2.1.-; Oxidoreductase
Chromosomal Location of mouse Ortholog: 10|10 A3
Cellular Component:  cytoplasm
Molecular Function:  aminomuconate-semialdehyde dehydrogenase activity; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; retinal dehydrogenase activity
Biological Process:  9-cis-retinoic acid biosynthetic process; retinal metabolic process; retinoic acid metabolic process
Reference #:  Q8BH00 (UniProtKB)
Alt. Names/Synonyms: 2-aminomuconic semialdehyde dehydrogenase; AL8A1; aldehyde dehydrogenase 8 family, member A1; Aldehyde dehydrogenase family 8 member A1; Aldh8a1; RAL; Raldh4; Retinal dehydrogenase 4; retinal dehydrogenase type 4
Gene Symbols: Aldh8a1
Molecular weight: 53,664 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
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ALDH8A1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene