CCR5
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. Belongs to the G-protein coupled receptor 1 family. Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. Note: This description may include information from UniProtKB.
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Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine |
Chromosomal Location of rat Ortholog: 8q32 |
Cellular Component:
cell surface; cytoplasm; endosome; external side of plasma membrane
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Molecular Function:
actin binding; C-C chemokine binding; C-C chemokine receptor activity; chemokine (C-C motif) ligand 5 binding; identical protein binding; protein binding; protein kinase binding
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Biological Process:
calcium ion transport; calcium-mediated signaling; cell chemotaxis; cell-cell signaling; cellular response to lipopolysaccharide; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; chemokine-mediated signaling pathway; chemotaxis; defense response; defense response to bacterium; fat cell differentiation; forebrain development; G protein-coupled receptor signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; leukocyte migration; MAPK cascade; negative regulation of axon extension; negative regulation of macrophage apoptotic process; negative regulation of neural precursor cell proliferation; positive regulation of cell killing; positive regulation of cell-cell adhesion; positive regulation of cytosolic calcium ion concentration; positive regulation of fever generation; positive regulation of gene expression; positive regulation of interleukin-1 beta production; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of tumor necrosis factor production; regulation of cell migration; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to cholesterol; response to ionizing radiation; response to lipopolysaccharide; signaling
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Reference #:
O08556
(UniProtKB)
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Alt. Names/Synonyms: C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; Ccr5; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; Ckr5; Cmkbr5; MIP-1 alpha receptor
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Gene Symbols: Ccr5
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Molecular weight:
41,031 Da
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Basal Isoelectric point:
9.3
Predict pI for various phosphorylation states
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