CCR5 Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. Belongs to the G-protein coupled receptor 1 family. Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine
Chromosomal Location of mouse Ortholog: 9 F4|9 75.05 cM
Cellular Component:  cell surface; cytoplasm; endosome; external side of plasma membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  actin binding; C-C chemokine binding; C-C chemokine receptor activity; chemokine (C-C motif) ligand 5 binding; chemokine binding; chemokine receptor activity; G protein-coupled receptor activity; protein kinase binding
Biological Process:  calcium ion transport; calcium-mediated signaling; cell chemotaxis; cell-cell signaling; chemotaxis; defense response; G protein-coupled receptor signaling pathway; immune response; inflammatory response; negative regulation of axon extension; negative regulation of cell migration; negative regulation of macrophage apoptotic process; negative regulation of neural precursor cell proliferation; neuron death; positive regulation of apoptotic process by virus; positive regulation of cell-cell adhesion; positive regulation of cytosolic calcium ion concentration; positive regulation of fever generation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of tumor necrosis factor production; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to cholesterol; signal transduction
Reference #:  P51682 (UniProtKB)
Alt. Names/Synonyms: AM4-7; C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; Ccr5; CD195; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; Cmkbr; Cmkbr5; MIP-1 alpha receptor
Gene Symbols: Ccr5
Molecular weight: 40,785 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene