CCR5 Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. Belongs to the G-protein coupled receptor 1 family. Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. Note: This description may include information from UniProtKB.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine

Chromosomal Location of human Ortholog: 3p21.31

Cellular Component: cell surface; cytoplasm; endosome; external side of plasma membrane; plasma membrane

Molecular Function: actin binding; C-C chemokine binding; C-C chemokine receptor activity; chemokine (C-C motif) ligand 5 binding; chemokine receptor activity; coreceptor activity; identical protein binding; phosphatidylinositol phospholipase C activity; protein binding; virus receptor activity

Biological Process: calcium ion transport; calcium-mediated signaling; cell chemotaxis; cell surface receptor signaling pathway; cell-cell signaling; cellular defense response; cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; chemotaxis; dendritic cell chemotaxis; G protein-coupled receptor signaling pathway; immune response; inflammatory response; MAPK cascade; negative regulation of macrophage apoptotic process; positive regulation of cytosolic calcium ion concentration; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to cholesterol; signaling; viral entry into host cell

Disease: Diabetes Mellitus, Insulin-dependent, 22; Hepatitis C Virus, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To; West Nile Virus, Susceptibility To

Reference #: P51681 (UniProtKB)

Alt. Names/Synonyms: C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5; C-C motif chemokine receptor 5 A159A; CC-CKR-5; CCCKR5; CCR-5; CCR5; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; chemokine recptor CCR5 Delta32; CHEMR13; CKR-5; CKR5; CMKBR5; FLJ78003; HIV-1 fusion coreceptor; IDDM22

Gene Symbols: CCR5

Molecular weight: 40,524 Da

Basal Isoelectric point: 9.21 Predict pI for various phosphorylation states

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CCR5

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