G-alpha 13 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Belongs to the G-alpha family. G(12) subfamily. Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(12)
Chromosomal Location of Human Ortholog: 11 E1|11 71.88 cM
Cellular Component:  brush border membrane; cytoplasm; cytosol; heterotrimeric G-protein complex; membrane; nucleus
Molecular Function:  D5 dopamine receptor binding; G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; guanyl nucleotide binding; metal ion binding; nucleotide binding; protein binding
Biological Process:  activation of phospholipase D activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; angiogenesis; branching involved in blood vessel morphogenesis; cell differentiation; G protein-coupled receptor signaling pathway; in utero embryonic development; intracellular signal transduction; platelet activation; positive regulation of cytosolic calcium ion concentration; regulation of cell migration; regulation of cell shape; Rho protein signal transduction; signal transduction
Reference #:  P27601 (UniProtKB)
Alt. Names/Synonyms: AU024132; AU043124; G alpha-13; G-alpha 13; G-protein subunit alpha-13; Galpha13; Gna-13; Gna13; guanine nucleotide binding protein, alpha 13; Guanine nucleotide-binding protein subunit alpha-13; OTTMUSP00000003361
Gene Symbols: Gna13
Molecular weight: 44,055 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
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G-alpha 13

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene