PICALM Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Vesicle
Chromosomal Location of Human Ortholog: 11q14.2
Cellular Component:  cell surface; clathrin-coated endocytic vesicle; clathrin-coated pit; clathrin-coated vesicle; cytosol; early endosome; endosome to plasma membrane transport vesicle; Golgi apparatus; intracellular membrane-bounded organelle; intrinsic component of membrane; neurofibrillary tangle; neuronal cell body; nucleus; plasma membrane; postsynaptic membrane; presynaptic membrane; vesicle
Molecular Function:  1-phosphatidylinositol binding; amyloid-beta binding; clathrin binding; clathrin heavy chain binding; low-density lipoprotein particle receptor binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; Rab GTPase binding; SNARE binding; tau protein binding
Biological Process:  amyloid-beta clearance by transcytosis; axonogenesis; cargo loading into vesicle; clathrin coat assembly; clathrin-coated pit assembly; clathrin-dependent endocytosis; dendrite morphogenesis; endocytosis; endosomal transport; hemopoiesis; iron ion homeostasis; learning or memory; membrane bending; membrane organization; modulation of age-related behavioral decline; negative regulation of gene expression; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process; negative regulation of protein localization to cell surface; negative regulation of protein localization to plasma membrane; negative regulation of receptor-mediated endocytosis; positive regulation of amyloid-beta formation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of GTPase activity; positive regulation of neuron death; positive regulation of transcription, DNA-templated; protein-containing complex assembly; receptor internalization; receptor-mediated endocytosis; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; regulation of endocytosis; regulation of protein localization; regulation of vesicle size; synaptic vesicle maturation; vesicle budding from membrane; vesicle-mediated transport
Disease: Leukemia, Acute Myeloid
Reference #:  Q13492 (UniProtKB)
Alt. Names/Synonyms: CALM; Clathrin assembly lymphoid myeloid leukemia protein; clathrin assembly lymphoid-myeloid leukemia; CLTH; LAP; phosphatidylinositol binding clathrin assembly protein; Phosphatidylinositol-binding clathrin assembly protein; PICAL; PICALM
Gene Symbols: PICALM
Molecular weight: 70,755 Da
Basal Isoelectric point: 7.7  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein