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ANPA
a transmembrane guanylyl cyclase enzyme with a tyrosine kinse domain. Receptor for natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction. Note: This description may include information from UniProtKB.
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| Protein type: EC 4.6.1.2; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc. |
| Chromosomal Location of rat Ortholog: 2q34 |
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Cellular Component:
membrane; plasma membrane; receptor complex
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Molecular Function:
adenylate cyclase activity; ATP binding; GTP binding; guanylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity; phosphorus-oxygen lyase activity; protein binding; protein kinase activity
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Biological Process:
blood vessel diameter maintenance; cell surface receptor signaling pathway; cGMP biosynthetic process; cGMP-mediated signaling; dopamine metabolic process; intracellular signal transduction; negative regulation of smooth muscle cell proliferation; positive regulation of cGMP-mediated signaling; protein phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure
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Reference #:
P18910
(UniProtKB)
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Alt. Names/Synonyms: ANP-A; ANPA; ANPR-A; Anpra; atrial natriuretic peptide A-type receptor; Atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor A; Atrial natriuretic peptide receptor type A; GC-A; Gca; Guanylate cyclase A; natriuretic peptide receptor 1; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); NPR-A; Npr1; Npra
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Gene Symbols: Npr1
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Molecular weight:
118,951 Da
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Basal Isoelectric point:
6.59
Predict pI for various phosphorylation states
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