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GAP43
This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Belongs to the neuromodulin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell surface |
| Chromosomal Location of Human Ortholog: 11q21 |
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Cellular Component:
axon; cell junction; cell periphery; cytoplasm; filopodium membrane; GABA-ergic synapse; growth cone; growth cone membrane; plasma membrane; postsynaptic density; presynapse
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Molecular Function:
calmodulin binding; lysophosphatidic acid binding; phosphatidylinositol phosphate binding; phosphatidylserine binding
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Biological Process:
axon choice point recognition; axon guidance; axon regeneration; cell fate commitment; glial cell differentiation; nervous system development; regulation of filopodium assembly; regulation of growth; regulation of postsynaptic specialization assembly; tissue regeneration
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Reference #:
P07936
(UniProtKB)
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Alt. Names/Synonyms: Axonal membrane protein GAP-43; Basp2; brain abundant, membrane attached signal protein 2; Gap43; growth accentuating protein 43; growth associated protein 43; Growth-associated protein 43; MGC156666; NEUM; Neuromodulin; Protein F1
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Gene Symbols: Gap43
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Molecular weight:
23,603 Da
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Basal Isoelectric point:
4.61
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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