GAP43 This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Belongs to the neuromodulin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 11q21
Cellular Component:  axon; cell junction; cell periphery; cytoplasm; filopodium membrane; GABA-ergic synapse; growth cone; growth cone membrane; plasma membrane; postsynaptic density; presynapse
Molecular Function:  calmodulin binding; lysophosphatidic acid binding; phosphatidylinositol phosphate binding; phosphatidylserine binding
Biological Process:  axon choice point recognition; axon guidance; axon regeneration; cell fate commitment; glial cell differentiation; nervous system development; regulation of filopodium assembly; regulation of growth; regulation of postsynaptic specialization assembly; tissue regeneration
Reference #:  P07936 (UniProtKB)
Alt. Names/Synonyms: Axonal membrane protein GAP-43; Basp2; brain abundant, membrane attached signal protein 2; Gap43; growth accentuating protein 43; growth associated protein 43; Growth-associated protein 43; MGC156666; NEUM; Neuromodulin; Protein F1
Gene Symbols: Gap43
Molecular weight: 23,603 Da
Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GAP43

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene