Kv9.3 Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed:22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed:10484328). Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 2p24.2
Cellular Component:  cytosol; Golgi apparatus; membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity; potassium channel regulator activity; voltage-gated potassium channel activity
Biological Process:  potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport
Reference #:  Q9BQ31 (UniProtKB)
Alt. Names/Synonyms: Delayed-rectifier K(+) channel alpha subunit 3; KCNS3; KV9.3; MGC9481; potassium voltage-gated channel delayed-rectifier protein S3; potassium voltage-gated channel modifier subfamily S member 3; Potassium voltage-gated channel subfamily S member 3; potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3; Shab-related delayed-rectifier K+ channel alpha subunit 3; voltage-gated potassium channel protein Kv9.3; Voltage-gated potassium channel subunit Kv9.3
Gene Symbols: KCNS3
Molecular weight: 56,001 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene